This policy brief was developed by UHC2030 International Health Partnership's Fragile Settings Technical Working Group and published in December, 2020. The paper presents: 1. Global guidance on COVID-19 response strategies that should be adapted to context-specific and evolving needs in fragile settings, 2. An urgent call to protect funding for health in fragile settings, 3. Six emergent lessons to enhance COVID-19 response and recovery in fragile settings.